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Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271859" target="_blank" >RIV/00216208:11150/14:10271859 - isvavai.cz</a>

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1111/jpi.12154/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jpi.12154/pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/jpi.12154" target="_blank" >10.1111/jpi.12154</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure

  • Original language description

    Melatonin was previously shown to reduce blood pressure and left ventricular remodeling in several models of experimental heart damage. Isoproterenol-induced heart failure with hypertrophy of the left and right ventricles, lowered systolic blood pressureand elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the LV and oxidative stress development. Melatonin failed to reduce the weight of the LV or RV; however, it curtailed the weight of the lungs and attenuated the decline in SBP. Moreover, melatonin decreased the level of oxidative stress and insoluble and total collagen. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol-induced heart damage.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Pineal Research

  • ISSN

    0742-3098

  • e-ISSN

  • Volume of the periodical

    57

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DK - DENMARK

  • Number of pages

    8

  • Pages from-to

    177-184

  • UT code for WoS article

    000342234000005

  • EID of the result in the Scopus database