Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10316910" target="_blank" >RIV/00216208:11150/15:10316910 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875485 RIV/00179906:_____/15:10316910
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.3109/09553002.2015.1054528" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/09553002.2015.1054528</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/09553002.2015.1054528" target="_blank" >10.3109/09553002.2015.1054528</a>

Result language
angličtina
Original language name
Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice
Original language description
Purpose: We examined the effect of epidermal growth factor (EGF) and bone marrow transplantation (BMT) on gastrointestinal damage after high-dose irradiation of mice. Material and methods: C57Black/6 mice were used. Two survival experiments were performed (12 and 13 Gy; 60Co, 0.59-0.57 Gy/min). To evaluate BMT and EGF action, five groups were established - 0 Gy, 13 Gy, 13 Gy + EGF (at 2 mg/kg, first dose 24 h after irradiation and then every 48 h), 13 Gy + BMT (5 x 106 cells from green fluorescent protein [GFP] syngenic mice, 4 h after irradiation), and 13 Gy + BMT + EGF. Survival data, blood cell counts, gastrointestine and liver parameters and GFP positive cell migration were measured. Results: BMT and EGF (three doses, at 2 mg/kg, administered 1, 3and 5 days after irradiation) significantly increased survival (13 Gy). In blood, progressive cytopenia was observed with BMT, EGF or their combination having no improving effect early after irradiation. In gastrointestinal system, BMT, E
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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