Epidermal growth factor attenuates delayed ionizing radiation- induced tissue damage in bone marrow transplanted mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F16%3A43875634" target="_blank" >RIV/60162694:G44__/16:43875634 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10327181 RIV/00179906:_____/16:10327181

Result on the web

<a href="http://www.rrjournal.org/doi/10.1667/RR14247.1" target="_blank" >http://www.rrjournal.org/doi/10.1667/RR14247.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RR14247.1" target="_blank" >10.1667/RR14247.1</a>

Result language

angličtina

Original language name

Epidermal growth factor attenuates delayed ionizing radiation- induced tissue damage in bone marrow transplanted mice

Original language description

We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy (Co-60, single dose, 0.51 Gy/min) with BMT (5 X 3 10(6) bone marrow cells isolated from green fluorescent protein syngeneic mice, 3-4 h postirradiation); and 11 Gy with BMT and EGF (2 mg/kg applied subcutaneously 1, 3 and 5 days postirradiation). Survival data were collected. Bone marrow, peripheral blood count and cytokines, gastrointestine and liver parameters and migration of green fluorescent protein-positive cells were evaluated at 63 days postirradiation. Epidermal growth factor increased survival of irradiated animals that received BMT from 10.7 to 85.7% at 180 days postirradiation. In the BMT group, we found changes in differential bone marrow and blood count, plasma cytokine levels, gastrointestinal tissues and liver at 63 days postirradiation. These alterations were completely or in some parameters at least partially restored by epidermal growth factor. These findings indicate that epidermal growth factor, administered 1, 3 and 5 days postirradiation in combination with bone marrow transplantation, significantly improves long-term prognosis. (c) 2016 by Radiation Research Society

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Research

ISSN

0033-7587

e-ISSN

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Volume of the periodical

186

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

264-274

UT code for WoS article

000384352000005

EID of the result in the Scopus database

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