Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F16%3A10327007" target="_blank" >RIV/00216208:11150/16:10327007 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12024-016-9764-2" target="_blank" >http://dx.doi.org/10.1007/s12024-016-9764-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12024-016-9764-2" target="_blank" >10.1007/s12024-016-9764-2</a>

Result language

angličtina

Original language name

Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases

Original language description

The aim of this study was to assess the diagnostic value of catecholamines and their O-methylated metabolites in vitreous humor samples in identifying antemortem cold exposure and fatal hypothermia in the forensic casework. A total of 80 autopsy cases (40 hypothermia fatalities and 40 cases in which hypothermia as the main or contributory cause of death was excluded) were selected for this study. Catecholamines and their O-methylated metabolites were measured in urine and vitreous humor samples collected at autopsy. Urine catecholamine and their O-methylated metabolite concentrations were significantly higher in hypothermia-related deaths. On the other hand, measurements in vitreous humor samples did not reveal statistically significant differences between hypothermia-related deaths and controls. Globally considered, our findings seem to suggest that, contrary to urine catecholamines and their O-methylated metabolites, vitreous levels of these compounds appear to be of limited value in characterizing human antemortem stress reactions due to cold exposure and can hardly be used in the forensic setting to support the diagnosis of hypothermia.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Forensic Science, Medicine, and Pathology

ISSN

1547-769X

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

163-169

UT code for WoS article

000376018300006

EID of the result in the Scopus database

2-s2.0-84961653133