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Neopterin as a biomarker of immune response in cancer patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10364342" target="_blank" >RIV/00216208:11150/17:10364342 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/17:10364342 RIV/00179906:_____/17:10364342 RIV/61989592:15110/17:73583804

  • Result on the web

    <a href="http://atm.amegroups.com/article/view/15415/html" target="_blank" >http://atm.amegroups.com/article/view/15415/html</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21037/atm.2017.06.29" target="_blank" >10.21037/atm.2017.06.29</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Neopterin as a biomarker of immune response in cancer patients

  • Original language description

    With the advent of immunotherapy the topic of biomarkers of immune response is of high interest. Along with the expression of programmed death ligand 1 (PD-L1) or tumor infiltrating lymphocytes (TIL), biomarkers of macrophage activation could be of interest. Neopterin is a biomarker of immune activation increased in different disorders associated with immune activation, including cancer. Neopterin synthesis is induced by interferon-gamma. that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine. Increased urinary or serum concentrations of neopterin have been associated with poor prognosis across a spectrum of malignant disorders of different primary location. Neopterin concentration in peripheral blood as well as in the tumor microenvironment correlates with phenotypic and functional changes of lymphocytes, indicating immune dysfunction. Increased neopterin concentrations are also accompanied by increased rate of conversion of tryptophan to kynurenine. Increasing neopterin concentrations also accompany side effects of anticancer treatment and could predict subsequent complications. Although almost four decades have elapsed since the discovery of increased neopterin concentrations in cancer patients, the full potential of neopterin as a biomarker in this setting has not been so far realized.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    <a href="/en/project/NV16-32030A" target="_blank" >NV16-32030A: Repurposing disulfiram as a novel treatment for chemo-endocrine therapy-resistant, recurrent metastatic breast cancer</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Annals of Translational Medicine

  • ISSN

    2305-5839

  • e-ISSN

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    13

  • Country of publishing house

    CN - CHINA

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    000408647900013

  • EID of the result in the Scopus database

    2-s2.0-85024884256