Neopterin as a biomarker of immune response in cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10364342" target="_blank" >RIV/00216208:11150/17:10364342 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/17:10364342 RIV/00179906:_____/17:10364342 RIV/61989592:15110/17:73583804
Result on the web
<a href="http://atm.amegroups.com/article/view/15415/html" target="_blank" >http://atm.amegroups.com/article/view/15415/html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21037/atm.2017.06.29" target="_blank" >10.21037/atm.2017.06.29</a>
Alternative languages
Result language
angličtina
Original language name
Neopterin as a biomarker of immune response in cancer patients
Original language description
With the advent of immunotherapy the topic of biomarkers of immune response is of high interest. Along with the expression of programmed death ligand 1 (PD-L1) or tumor infiltrating lymphocytes (TIL), biomarkers of macrophage activation could be of interest. Neopterin is a biomarker of immune activation increased in different disorders associated with immune activation, including cancer. Neopterin synthesis is induced by interferon-gamma. that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine. Increased urinary or serum concentrations of neopterin have been associated with poor prognosis across a spectrum of malignant disorders of different primary location. Neopterin concentration in peripheral blood as well as in the tumor microenvironment correlates with phenotypic and functional changes of lymphocytes, indicating immune dysfunction. Increased neopterin concentrations are also accompanied by increased rate of conversion of tryptophan to kynurenine. Increasing neopterin concentrations also accompany side effects of anticancer treatment and could predict subsequent complications. Although almost four decades have elapsed since the discovery of increased neopterin concentrations in cancer patients, the full potential of neopterin as a biomarker in this setting has not been so far realized.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/NV16-32030A" target="_blank" >NV16-32030A: Repurposing disulfiram as a novel treatment for chemo-endocrine therapy-resistant, recurrent metastatic breast cancer</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of Translational Medicine
ISSN
2305-5839
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
13
Country of publishing house
CN - CHINA
Number of pages
12
Pages from-to
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UT code for WoS article
000408647900013
EID of the result in the Scopus database
2-s2.0-85024884256