Lipoprotein Apheresis in the Treatment of Dyslipidemia - the Czech Republic Experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10365982" target="_blank" >RIV/00216208:11150/17:10365982 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/17:10365982

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lipoprotein Apheresis in the Treatment of Dyslipidemia - the Czech Republic Experience

Original language description

In 1984, we started using therapeutic plasmapheresis (plasma exchange) as a method of extracorporeal lipoprotein elimination for the treatment of hypercholesterolemic patients. We evaluated the results of long-term therapy in 14 patients, 8 men and 6 women. The average age was 55.6 +/- 13.2 (range 28-70), median 59.5 years.14 patients were diagnosed with familial hypercholesterolemia (FH): 5 homozygous, 9 heterozygous. Ten patients in the group were treated using immunoadsorption lipoprotein apheresis and 4 using hemorheopheresis. Immunoapheretic interventions decreased LDL-cholesterol (82 +/- 1 %), ApoB (73 +/- 13 %) and even Lp( a) by 82 +/- 19 %, respectively. Selected non-invasive methods are important for long-term and repeated follow-up. Carotid intima-media thickness showed improvement or stagnation in 75 % of the patients. Biomarkers of endothelial dysfunction such as endoglin ( in the control group:3.85 +/- 1.25 mu g/l, in lipoprotein apheresis-treated hypercholesterolemic individuals 5.74 +/- 1.47 mu g/l), CD40 ligand (before lipoprotein apheresis:6498 +/- 2529 ng/l, after lipoprotein apheresis: 4057 +/- 2560 ng/l) and neopterin (before lipoprotein apheresis: 5.7 +/- 1.1 nmol/l, after lipoprotein apheresis: 5.5 +/- 1.3 nmol/l) related to the course of atherosclerosis, but did not reflect the actual activity of the disease nor facilitate the prediction or planning of therapy. Hemorheopheresis may improve blood flow in microcirculation in familial hypercholesterolemia and also in some other microcirculation disorders via significantly decreased activity of thrombomodulin (p &lt; 0.0001), tissue factor (p &lt; 0.0001), aggregation of thrombocytes (p&lt; 0.0001) and plasma and whole blood viscosity (p &lt; 0.0001). In conclusion, lipoprotein apheresis and hemorheopheresis substantially lowered LDL-cholesterol in severe hypercholesterolemia. Our experience with long-term therapy also shows good tolerance and a small number of complications (6.26 % non-serious clinical complications).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV17-28882A" target="_blank" >NV17-28882A: Genetic plymorphisms, MicroRNAs and bioindicators of activity: interrelations in the diagnostics and therapy of severe familial hypercholesterolemia</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

"S91"-"S100"

UT code for WoS article

000398620900011

EID of the result in the Scopus database

2-s2.0-85017145448