S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10375153" target="_blank" >RIV/00216208:11150/17:10375153 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/17:10375153

Result on the web

<a href="https://actamedica.lfhk.cuni.cz/60/3/0108/" target="_blank" >https://actamedica.lfhk.cuni.cz/60/3/0108/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2018.2" target="_blank" >10.14712/18059694.2018.2</a>

Result language

angličtina

Original language name

S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Original language description

Introduction: The aim of our study was to assess association of serum S100A4 protein with ulcerative colitis (UC) and Crohn&apos;s disease (CD). Methods: Study included 118 subjects: 93 patients with CD, 16 with UC and 9 controls. In CD group, 20/93 patients had B1 phenotype, 19/93 B2, 20/93 B3 and 34/93 B2 + B3. L1 involvement was present in 15/93, L2 in 14/93 and L3 in 64/93 patients. Serum S100A4 concentration was investigated in peripheral venous blood samples by means of ELISA. Results: Serum S100A4 was significantly higher in UC (158.6 +- 56.2 ng/mL), p = 0.019 and in CD (154.4 +- 52.1 ng/mL), p = 0.007 compared to controls (104.8 +- 40.5 ng/mL). No difference in S100A4 was revealed between UC and CD, p &gt; 0.05. Serum S100A4 in each CD subgroup (according to behaviour) was significantly higher compared to controls, p &lt; 0.05. Serum S100A4 was significantly higher in L2 (144.6 +- 44.2 ng/mL), p = 0.041 and in L3 (163.0 +- 52.8 ng/mL), p = 0.002 compared to controls and in L3 compared to L1 (126.9 +- 47.6 ng/mL), p = 0.017. Conclusion: Association of serum S100A4 protein with UC and CD was confirmed. In CD, disease behaviour did not influence serum concentration of S100A4 protein. In CD, higher levels of serum S100A4 were observed in patients with ileo-colonic and colonic involvement compared to those with isolated small bowel involvement.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Medica (Hradec Králové)

ISSN

1211-4286

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

108-113

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85046283311