Hepcidin in newly diagnosed inflammatory bowel disease in children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590124" target="_blank" >RIV/61989592:15110/18:73590124 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/18:N0000079

Result on the web

<a href="http://dx.doi.org/10.1111/jpc.14093" target="_blank" >http://dx.doi.org/10.1111/jpc.14093</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jpc.14093" target="_blank" >10.1111/jpc.14093</a>

Result language

angličtina

Original language name

Hepcidin in newly diagnosed inflammatory bowel disease in children

Original language description

Aim: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn&apos;s disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. Methods: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study. We analysed levels of serum hepcidin, C-reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse-phase liquid chromatography. The Paediatric Crohn&apos;s Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. Results: Subjects with CD (n = 53) had significantly higher serum hepcidin levels compared with subjects with UC (n = 23) – 22.6 ng/mL (range 8.5–65.0) versus 6.5 ng/mL (range 2.4–25.8) (P &lt; 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients (P &lt; 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count (P &lt; 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin (P &lt; 0.05) in children with UC. Conclusion: Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment. © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

<a href="/en/project/GA15-13732S" target="_blank" >GA15-13732S: Molecular basis of erythroid defect and disrupted iron metabolism in DMT1 deficiency and Diamond-Blackfan anemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF PAEDIATRICS AND CHILD HEALTH

ISSN

1034-4810

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

12

Country of publishing house

AU - AUSTRALIA

Number of pages

6

Pages from-to

1362-1367

UT code for WoS article

000453386100014

EID of the result in the Scopus database

2-s2.0-85057628254