Changes in serum hepcidin levels in children with inflammatory bowel disease during anti-inflammatory treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73596325" target="_blank" >RIV/61989592:15110/20:73596325 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/20:N0000065

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jpc.14593" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jpc.14593</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jpc.14593" target="_blank" >10.1111/jpc.14593</a>

Result language

angličtina

Original language name

Changes in serum hepcidin levels in children with inflammatory bowel disease during anti-inflammatory treatment

Original language description

Aim The aim of this study was to compare changes in serum hepcidin levels in paediatric patients with inflammatory bowel disease during therapy and correlate them with markers of iron metabolism, inflammation and type of treatment. Methods Children with newly diagnosed Crohn&apos;s disease (CD) and ulcerative colitis (UC) were included in this longitudinal study. Blood and stool samples were collected to assess levels of serum hepcidin and markers of iron metabolism parameters and inflammation. The parameters were examined before treatment (baseline levels) and compared with levels in the follow-up period during maintenance therapy (mean follow-up of 39 months after diagnosis). Results Patients with CD (n = 30) had higher serum hepcidin levels (expressed as a median and interquartile range) at diagnosis than subjects with UC (n = 13). These levels significantly decreased during the follow-up (from 36.5 (11.5-79.6) to 2.1 (0.9-6.7) ng/mL). In contrast, no significant serum hepcidin level changes were observed in the UC patients (5.4 (3.4-16.6) vs. 4.8 (0.9-8.1) ng/mL). While hepcidin level changes correlated with disease activity and inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein), in CD patients, they correlated only with serum iron levels in patients with UC. Biological therapy was accompanied by a significant decrease in C-reactive protein and interleukin-6 compared to conventional anti-inflammatory therapy in CD patients. Conclusions Children with CD had higher serum hepcidin levels on diagnosis compared to subjects with UC. During an anti-inflammatory therapy, serum hepcidin decreased in the CD group but remained consistently low in children with UC.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF PAEDIATRICS AND CHILD HEALTH

ISSN

1034-4810

e-ISSN

—

Volume of the periodical

56

Issue of the periodical within the volume

2

Country of publishing house

AU - AUSTRALIA

Number of pages

7

Pages from-to

276-282

UT code for WoS article

000481219600001

EID of the result in the Scopus database

2-s2.0-85070781428