Cervical fluid interleukin 6 and intra-amniotic complications of preterm prelabor rupture of membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10370872" target="_blank" >RIV/00216208:11150/18:10370872 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/18:10370872

Result on the web

<a href="http://dx.doi.org/10.1080/14767058.2017.1297792" target="_blank" >http://dx.doi.org/10.1080/14767058.2017.1297792</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14767058.2017.1297792" target="_blank" >10.1080/14767058.2017.1297792</a>

Result language

angličtina

Original language name

Cervical fluid interleukin 6 and intra-amniotic complications of preterm prelabor rupture of membranes

Original language description

To determine if cervical fluid interleukin (IL)-6 concentrations in women with preterm prelabor rupture of membranes (PPROM) allows identification of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI). One hundred forty-four women with singleton pregnancies complicated by PPROM were included in this prospective cohort study. Cervical and amniotic fluids were collected at the time of admission and concentrations of IL-6 were measured using an ELISA and point-of-care test, respectively. Cervical fluid was obtained using a Dacron polyester swab and amniotic fluid was obtained by transabdominal amniocentesis. MIAC was diagnosed based on a positive PCR result for Ureaplasma species, M. hominis, and/or C. trachomatis and/or by positivity for the 16 S rRNA gene. IAI was defined as amniotic fluid point-of-care IL-6 concentrations &gt;=745 pg/mL. The women were assigned to four subgroups based on the presence of MIAC and/or IAI: microbial-associated IAI (both MIAC and IAI), sterile IAI (IAI alone), MIAC alone, and without either MIAC or IAI. Women with microbial-associated IAI had higher cervical fluid IL-6 concentrations (median 560 pg/mL) than did women with sterile IAI (median 303 pg/mL; p =.001), women with MIAC alone (median 135 pg/mL; p =.0004), and women without MIAC and IAI (median 180 pg/mL; p =.0001). No differences were found in cervical fluid IL-6 concentrations among women with sterile IAI, with MIAC alone, and without MIAC and IAI. A positive correlation was observed between cervical fluid IL-6 concentrations and the amount of Ureaplasma species in amniotic fluid (copies DNA/mL; rho = 0.57, p &lt;.0001). A weak positive correlation was detected between cervical and amniotic fluid IL-6 concentrations (rho = 0.33, p &lt;.0001). The presence of microbial-associated IAI is associated with the highest cervical fluid IL-6 concentrations. Cervical IL-6 can be helpful in the identification of microbial-associated IAI

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

827-836

UT code for WoS article

000428644300001

EID of the result in the Scopus database

2-s2.0-85014804274