3-Quinuclidinyl benzilate (agent BZ) toxicokinetics in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10430279" target="_blank" >RIV/00216208:11150/21:10430279 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/21:00557158 RIV/00216208:11160/21:10430279
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YNmOcUa0ec" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YNmOcUa0ec</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.13627" target="_blank" >10.1111/bcpt.13627</a>

Result language
angličtina
Original language name
3-Quinuclidinyl benzilate (agent BZ) toxicokinetics in rats
Original language description
3-Quinuclidinyl benzilate (BZ) ranks among incapacitating military warfare agents. It acts as a competitive inhibitor on muscarinic receptors leading to non-lethal mental impairment. The present study aimed to investigate toxicokinetics of BZ in rats. Moreover, BZ can be exploited to produce a pharmacological model of Alzheimer's disease; thus, this paper focuses mainly on the BZ distribution to the brain. Wistar rats were administered i.p. with BZ (2 and 10 mg/kg). The BZ concentration was determined using LC-MS/MS in plasma, urine, bile, brain, kidney and liver. The sample preparation was based on a solid phase extraction (liquids) or protein precipitation (organ homogenates). The plasma concentration peaked at 3 min (204.5 +/- 55.4 and 2185.5 +/- 465.4 ng/ml). The maximal concentration in the brain was reached several minutes later. Plasma elimination half-life was 67.9 +/- 3.4 in the 2 mg/kg group and 96.6 +/- 27.9 in the 10 mg/kg group. BZ concentrations remained steady in the brain, with slow elimination (t(1/2) 506.9 +/- 359.5 min). Agent BZ is excreted mainly via the urine. Steady BZ concentration in the brain could explain the previously published duration of the significant impairment in passive avoidance tasks in rats after an injection of BZ.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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