A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: Lowering sample complexity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145825" target="_blank" >RIV/00216208:11160/13:10145825 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0021967313016270" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967313016270</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chroma.2013.10.027" target="_blank" >10.1016/j.chroma.2013.10.027</a>

Result language
angličtina
Original language name
A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: Lowering sample complexity
Original language description
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) brings unique combined information on molecular identity and molecular distribution of a sample surface. During the past decade, it has matured and is now routinely employed for biomedical tissue sections analysis. However, owing to the high molecular complexity of tissue, MALDI-MSI suffers from ionization suppression effects. This directly results in a reduced ability to detect low-abundant molecular species. At the same time, the spatial resolution of separation techniques can be insufficient for an unambiguous determination of the local composition of a mixture. As analytical separation techniques can significantly reduce ion suppression, and MALDI-MSI has an abilityto improve their spatial resolution, the two analytical approaches can successfully be combined in a pursuit of comprehensive local sample composition information. In the following review we summarize strategies of mutually beneficial co
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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