Investigation of Potential Inhibitors of Chorismate-Utilizing Enzymes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312614" target="_blank" >RIV/00216208:11160/15:10312614 - isvavai.cz</a>

Result on the web

<a href="http://benthamscience.com/journals/current-medicinal-chemistry/volume/22/issue/11/page/1383/" target="_blank" >http://benthamscience.com/journals/current-medicinal-chemistry/volume/22/issue/11/page/1383/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867322666150209152446" target="_blank" >10.2174/0929867322666150209152446</a>

Result language

angličtina

Original language name

Investigation of Potential Inhibitors of Chorismate-Utilizing Enzymes

Original language description

Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria. The absence of these enzymes in humans and their importance in the virulence and survival of bacteria make them suitable targets for potential antimicrobial compounds. Furthermore, the CUE have significant structural homology and similar catalytic mechanisms, enabling the strategy of affecting multiple enzymes with one single inhibitor. This review follows up the investigation of mechanisms of CUE-catalysed reactions and the concurrent development of CUE inhibitors. Many active compounds were found amongst the structures mimicking the transition state of chorismate during the reaction. Most recently, high nanomolar and low micromolar inhibitors against isochorismate-pyruvate lyase were identi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

11

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

17

Pages from-to

1383-1399

UT code for WoS article

000351863400007

EID of the result in the Scopus database

2-s2.0-84925632057