Mucoadhesive plasticized system of branched poly(lactic-co-glycolic acid) with aciclovir
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10323493" target="_blank" >RIV/00216208:11160/16:10323493 - isvavai.cz</a>
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.3109/03639045.2016.1160109" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/03639045.2016.1160109</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03639045.2016.1160109" target="_blank" >10.3109/03639045.2016.1160109</a>
Alternative languages
Result language
angličtina
Original language name
Mucoadhesive plasticized system of branched poly(lactic-co-glycolic acid) with aciclovir
Original language description
The purpose of this work is to formulate a mucoadhesive system with aciclovir (ACV) based on a solid molecular dispersion of this drug in poly(lactic-co-glycolic acid) branched on tripenterythritol (PLGA/T). The ACV incorporation into PLGA/T was carried out either by solvent method, or melting method, or plasticization method using various plasticizers. The drug-polymer miscibility, plasticizer efficiency and content of residual solvent were found out employing DSC. Viscosity was measured at the shear rate range from 0.10 to 10.00 s(-1) at three temperatures and data were analyzed by Newtonian model. The mucoadhesive properties were ascertained in the tensile test on a mucin substrate. The amount of ACV released was carried out in a wash-off dissolution test. The DSC results indicate a transformation of crystalline form of ACV into an amorphous dissolved in branched polyester carrier, and absence of methyl formate residuals in formulation. All the tested plasticizers are efficient at Tg depression and viscosity decrease. The non-conventional ethyl pyruvate possessing supportive anti-inflammatory activity was evaluated as the most suitable plasticizer. The ACV release was strongly dependent on the ethyl pyruvate concentration and lasted from 1 to 10 days. The formulated PLGA/T system with ACV exhibits increased adhesion to mucosal hydrophilic surfaces and prolonged ACV release controllable by degradation process and viscosity parameters.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Development and Industrial Pharmacy
ISSN
0363-9045
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1653-1659
UT code for WoS article
000380917700012
EID of the result in the Scopus database
2-s2.0-84964999905