Mono and dihydroxy coumarin derivatives: Copper chelation and reduction ability

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381848" target="_blank" >RIV/00216208:11160/18:10381848 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0946672X17307137" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0946672X17307137</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jtemb.2017.11.014" target="_blank" >10.1016/j.jtemb.2017.11.014</a>

Result language
angličtina
Original language name
Mono and dihydroxy coumarin derivatives: Copper chelation and reduction ability
Original language description
This study tested the interaction of a series of natural coumarins and their synthetic analogs with copper. Both competitive and non-competitive methods have been employed. Non-competitive studies showed that cuprous ions are not chelated at all and that the stoichiometries of the most active 6,7- and 7,8-dihydroxycoumarins to cupric ions ranged from 1:1 to 2:1 depending on pH and concentration. Interestingly, under highly competitive conditions, coumarins were not capable of chelating cupric ions, either. Reduction experiments have shown that 13 out of the 15 coumarins included in this study reduced cupric ions. However, significant differences depending on their structures were apparent in their potencies. O-dihydroxycoumarins were the most potent ones again.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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