Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F22%3A10450685" target="_blank" >RIV/00216208:11160/22:10450685 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_pUTVPpjv6" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_pUTVPpjv6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules27196429" target="_blank" >10.3390/molecules27196429</a>

Result language

angličtina

Original language name

Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper

Original language description

Data on alkaloid interactions with the physiologically important transition metals are mostly lacking in the literature. 28 isoquinoline alkaloids were selected for a complex screening of interactions with iron and copper at four pathophysiologically relevant pH and in non-buffered conditions . With the exception of the salts, all the alkaloids were able to chelate ferrous and ferric ions in non-buffered conditions, but only five of them evoked some significant chelation at pH 7.5 and only the first two were also active at pH 6.8. By contrast, none of the tested alkaloids chelated cuprous or cupric ions. All the alkaloids, with the exception of the protopines, significantly reduced the ferric and cupric ions, with stronger effects on the latter. As most of the alkaloids chelated and reduced the ferric ions, additional experimental studies are needed to elucidate the biological relevance of these results, as chelation is expected to block reactive oxygen species formation, while reduction could have the opposite effect.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

19

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

6429

UT code for WoS article

000866979000001

EID of the result in the Scopus database

2-s2.0-85139953158