A simple, cheap but reliable method for evaluation of zinc chelating properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381854" target="_blank" >RIV/00216208:11160/18:10381854 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0045206817308246" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0045206817308246</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2018.01.015" target="_blank" >10.1016/j.bioorg.2018.01.015</a>
Alternative languages
Result language
angličtina
Original language name
A simple, cheap but reliable method for evaluation of zinc chelating properties
Original language description
The aim of this work was to prepare a reliable, rapid and cheap method for the screening of zinc chelation. Spectrophotometric assessment using a known zinc indicator dithizone was selected. Initial screening suggested 530 and 570 nm as suitable wavelengths for determination of zinc at pH 4.5 while 540 and 590 nm for pH 5.5-7.5. Additional research showed the lower wavelengths to be more suitable. The sensitivity of the method was always bellow 1 microM with good linearity relationship between absorbance and zinc concentration. The method suitability was confirmed by use of two known zinc chelators, ethylenediaminetetraacetic acid (EDTA) and N,N,N',N'-tetrakis(2-pyridylmethyl)-1,2-ethylenediamine (TPEN).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
287-292
UT code for WoS article
000428013300030
EID of the result in the Scopus database
2-s2.0-85041670282