Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417877" target="_blank" >RIV/00216208:11160/20:10417877 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=T9cHV4oD6k" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=T9cHV4oD6k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2020.110732" target="_blank" >10.1016/j.biopha.2020.110732</a>

Result language

angličtina

Original language name

Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates

Original language description

Polyphenolic compounds are largely metabolized in the colon by microflora in plethora of small metabolites. These metabolites are largely absorbed and can hence have systemic effects. In this paper, the interaction of some parent polyphenolic compounds and metabolites with 2D6 cytochrome was analyzed emloying two different substrates for CYP2D6. Parent compounds were in general more potent inhibitors than metabolites. The inhibition toward both substrates was not equal which means some 2D6 substrate dependence.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicine &amp; Pharmacotherapy

ISSN

0753-3322

e-ISSN

—

Volume of the periodical

131

Issue of the periodical within the volume

November

Country of publishing house

FR - FRANCE

Number of pages

9

Pages from-to

110732

UT code for WoS article

000582699600102

EID of the result in the Scopus database

2-s2.0-85090955955