Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10433673" target="_blank" >RIV/00216208:11160/21:10433673 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gpyf-V6PKm" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gpyf-V6PKm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/star.202000166" target="_blank" >10.1002/star.202000166</a>

Result language

angličtina

Original language name

Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches

Original language description

Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized starches, namely, Starch 1500 and Lycatab C, from the perspectives of compressibility, compactability, and lubricant sensitivity. Compressibility is evaluated by means of the compression energy profile and a stress relaxation test. Compactability is evaluated by means of the tablets tensile strength, and lubricant sensitivity is characterized by the lubricant sensitivity ratio (LSR) values. The lubricants employed are magnesium stearate and sodium stearyl fumarate at concentrations of 0.5% and 1%, respectively. In the case of the mixtures with 1% magnesium stearate, the influence of the mixing time is also evaluated. Starch 1500 shows better compressibility than Lycatab C due to its lower precompression and total energy values. On the opposite, the plasticity is higher for Lycatab C. This material has also better compactability, yields stronger tablets, but has higher lubricant sensitivity than Starch 1500. Different compressibility and compactability are found for Lycatab C and Starch 1500 and therefore, they cannot be easily interchanged in tablet manufacture.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Starch/Staerke

ISSN

0038-9056

e-ISSN

—

Volume of the periodical

73

Issue of the periodical within the volume

3-4

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

2000166

UT code for WoS article

000596116900001

EID of the result in the Scopus database

2-s2.0-85097181744