Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000301" target="_blank" >RIV/00216208:11310/09:10000301 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/09:00328588

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors

Original language description

Purinergic P2X receptors, activated by extracellular ATP, play a role in pain sensation and immune response. We studied the structure of the first transmembrane domains of the P2X4 receptor, and functional role of conserved tyrosine and other aromatic amino acids in five subtypes of P2X family. We found that aromatic residues contribute to regulation of agonist binding at P2X1, P2X2, P2X3, P2X4 and P2X7 receptors, and play an important role in channel gating.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurochemistry

ISSN

0022-3042

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000265013700022

EID of the result in the Scopus database

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