Identification and characterization of repetitive extragenic palindromes (REP)-associated tyrosine transposases: implications for REP evolution and dynamics in bacterial genomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10001250" target="_blank" >RIV/00216208:11310/10:10001250 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Identification and characterization of repetitive extragenic palindromes (REP)-associated tyrosine transposases: implications for REP evolution and dynamics in bacterial genomes

Original language description

Bacterial repetitive extragenic palindromes (REPs) compose a distinct group of genomic repeats. They occur in high abundance (>100 copies/genome) and are often arranged in mosaic elements (BIMEs). In BIMEs, regularly spaced REPs are present in alternating orientations. BIMEs and REPs play role in chromosome organization and transcription termination. Their origins are, unknown. In this report, we describe a novel class of putative transposases related to IS200/IS605 transposase family and we demonstratethat they are obligately associated with bacterial REPs. Open reading frames coding these tyrosine transposases (RAYTs) are always flanked by two REPs in inverted orientation and thus constitute typical transposable elements. RAYTs and their flanking REPs apparently coevolve with each other. We propose that RAYTs are responsible for establishment of REPs and BIMEs in bacterial genomes. We suggest that BIMEs are a special type of nonautonomous transposable elements, mobilizable by RAYTs.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

—

Project

<a href="/en/project/LC06066" target="_blank" >LC06066: Center for Environmental Microbiology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Genomics

ISSN

1471-2164

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

leden

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—