Dissociation of nystatin and amphotericin analogues: characterisation of minor anti-fungal macrolides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10116644" target="_blank" >RIV/00216208:11310/10:10116644 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1255/ejms.1027" target="_blank" >http://dx.doi.org/10.1255/ejms.1027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1255/ejms.1027" target="_blank" >10.1255/ejms.1027</a>

Result language
angličtina
Original language name
Dissociation of nystatin and amphotericin analogues: characterisation of minor anti-fungal macrolides
Original language description
Tandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FT-ICR) has been the basis for rationalizing the fragmentation mechanisms of anti-fungal macrolides nystatin A(1) amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules Led to structurally significant ring-opened fragments. Using this approach of tandem FT-ICR mass spectrometry and electrospray ionisation coupled with high-performance Liquid chromatography (HPLC), 11 macrolide natural analogues or degradation products were characterised in the nystatin mixture.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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