Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10051856" target="_blank" >RIV/00216208:11310/11:10051856 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/11:00358984 RIV/00023001:_____/11:00002747 RIV/67985858:_____/11:00358984 RIV/68378041:_____/11:00358984
Result on the web
<a href="http://dx.doi.org/10.1039/c0jm01258k" target="_blank" >http://dx.doi.org/10.1039/c0jm01258k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c0jm01258k" target="_blank" >10.1039/c0jm01258k</a>

Result language
angličtina
Original language name
Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles
Original language description
The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moietywhile the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin-spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BM - Solid-state physics and magnetism
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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