Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10102982" target="_blank" >RIV/00216208:11310/11:10102982 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.5562/cca1738" target="_blank" >http://dx.doi.org/10.5562/cca1738</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5562/cca1738" target="_blank" >10.5562/cca1738</a>

Result language

angličtina

Original language name

Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE

Original language description

The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude lower in HPLC thanin CZE. As expected, elution order was found to be different for the both techniques. As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable for determination of the set of benzodiazepines. A real sample analysis was performed under optimized conditions to demonstrate applicability of the proposed analytical methods.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA203%2F08%2F1428" target="_blank" >GA203/08/1428: Capillary electrophoresis with multidimensinal detection and its application to separation and characterization of biopolymers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Croatica Chemica Acta

ISSN

0011-1643

e-ISSN

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Volume of the periodical

84

Issue of the periodical within the volume

3

Country of publishing house

HR - CROATIA

Number of pages

7

Pages from-to

367-373

UT code for WoS article

000298934200006

EID of the result in the Scopus database

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