Determination of Aminoglutethimide Using HPLC-ED on CPE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105116" target="_blank" >RIV/00216208:11310/11:10105116 - isvavai.cz</a>
Result on the web
<a href="http://www.bestservis.eu/Rakce/lang" target="_blank" >http://www.bestservis.eu/Rakce/lang</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Determination of Aminoglutethimide Using HPLC-ED on CPE
Original language description
This work deals with the determination of aminoglutethimide (AGT) using high performance liquid chromatography with UV spectrophotometric detection (HPLC-UV) and amperometric detection (HPLC-ED) on carbon paste electrode (CPE). AGT was used as anticancerdrug, especially for the treatment of breast cancer in postmenopausal women or for the treatment of prostate cancer. The concentration dependences of AGT were measured by HPLC-UV with detection wavelength 242 nm, by HPLC-ED with a working potencial of +1.3 V in mobile phase consisting of 1.10-2 mol l-1 phosphate buffer (pH 4) and methanol 50:50 (v/v). The following limits of detection were achieved : 3.6.10-7 mol l-1 AGT for UV spectrophotometric detection, 2.5.10-7 mol l-1 AGT for amperometric detection. AGT was also determined in model samples of urine. It was not possible to detect AGT with HPLC-UV, because of the interferences of other compounds. With HPLC-ED the detection limit 5.2.10-7 mol l-1 AGT was achieved.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Moderní elektrochemické metody: sborník přednášek XXXI. mezinárodní odborné konference: Jetřichovice 23. ? 27. května 2011
ISBN
978-80-254-9634-3
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
181-184
Publisher name
BEST servis Ústí nad Labem
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 23, 2011
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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