Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105194" target="_blank" >RIV/00216208:11310/11:10105194 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tet.2011.08.079" target="_blank" >http://dx.doi.org/10.1016/j.tet.2011.08.079</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tet.2011.08.079" target="_blank" >10.1016/j.tet.2011.08.079</a>

Result language
angličtina
Original language name
Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines
Original language description
The synthesis of piperidines and piperidines derivatives in enantiopure fashion have been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the "in situ" intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine-oxazolidines.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GP203%2F09%2FP193" target="_blank" >GP203/09/P193: Enantioselective synthesis of N- and S-containing heterocycles via organocatalysis: The way for preparation of biologically active compounds.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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