Molecular Cytogenetic Characterization in Four Pediatric Pheochromocytomas and Paragangliomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10107123" target="_blank" >RIV/00216208:11310/11:10107123 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/11:9881 RIV/00216208:11130/11:7154 RIV/61989592:15110/11:10224809 RIV/00064203:_____/11:7154

Result on the web

<a href="http://dx.doi.org/10.1007/s12253-011-9385-8" target="_blank" >http://dx.doi.org/10.1007/s12253-011-9385-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12253-011-9385-8" target="_blank" >10.1007/s12253-011-9385-8</a>

Result language

angličtina

Original language name

Molecular Cytogenetic Characterization in Four Pediatric Pheochromocytomas and Paragangliomas

Original language description

Pheochromocytomas (PCCs) are rare tumors among children and adolescents and therefore are not genetically well characterized. The most frequently observed chromosomal changes in PCC are losses of 1p, 3q and/or 3p, 6q, 17p, 11q, 22q, and gains of 9q and 17q. Aberrations involving chromosome 11 are more common in malignant tumors. Unfortunately information about gene aberrations in childhood PCC's is limited. We used comparative genomic hybridization (CGH) and array comparative genomic hybridization (aCGH) to screen for copy number changes in four children suffering from pheochromocytoma or paraganglioma. Patients were diagnosed at the age 13 or 14 years. Bilateral pheochromocytoma was associated with von Hippel-Lindau syndrome (VHL). Multiple paraganglioma was associated with a germline mutation in SDHB. We found very good concordance between the results of CGH and aCGH techniques. Losses were observed more frequently than gains. All cases had a loss of chromosome 11 or 11p. Other aberr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathology Oncology Research

ISSN

1219-4956

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

801-808

UT code for WoS article

000295588000003

EID of the result in the Scopus database

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