Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10125455" target="_blank" >RIV/00216208:11310/12:10125455 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2478/s11532-012-0056-8" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0056-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11532-012-0056-8" target="_blank" >10.2478/s11532-012-0056-8</a>

Result language

angličtina

Original language name

Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Original language description

New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrodepassivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 mu mol L-1 and 0.015 mmol L-1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Chemistry

ISSN

1895-1066

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

1310-1317

UT code for WoS article

000304618900035

EID of the result in the Scopus database

—