Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10125455" target="_blank" >RIV/00216208:11310/12:10125455 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/s11532-012-0056-8" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0056-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11532-012-0056-8" target="_blank" >10.2478/s11532-012-0056-8</a>
Alternative languages
Result language
angličtina
Original language name
Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode
Original language description
New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrodepassivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 mu mol L-1 and 0.015 mmol L-1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European Journal of Chemistry
ISSN
1895-1066
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
4
Country of publishing house
PL - POLAND
Number of pages
8
Pages from-to
1310-1317
UT code for WoS article
000304618900035
EID of the result in the Scopus database
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