Evaluation of damage to DNA induced by UV-C radiation and chemical agents using electrochemical biosensor based on low molecular weight DNA and screen-printed carbon electrode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10126368" target="_blank" >RIV/00216208:11310/12:10126368 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.electacta.2012.03.119" target="_blank" >http://dx.doi.org/10.1016/j.electacta.2012.03.119</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.electacta.2012.03.119" target="_blank" >10.1016/j.electacta.2012.03.119</a>

Result language

angličtina

Original language name

Evaluation of damage to DNA induced by UV-C radiation and chemical agents using electrochemical biosensor based on low molecular weight DNA and screen-printed carbon electrode

Original language description

There is great interest and need to detect and evaluate damage to DNA by environmental factors. In the present paper, simple electrochemical DNA biosensors composed of commercially available screen-printed carbon electrode (SPCE) and low molecular weightdouble-stranded DNA (dsDNA) recognition layer are reported and applied to the detection of damage to DNA by UV-C radiation and reactive oxygen species produced by the Fenton type reaction in model as well as mineral water samples with additives. ComplexDNA biosensor response is based on square-wave voltammetric intrinsic signal of the guanine moiety as well as that of the intercalative indicator thioridazine, cyclic voltammetric response of the [Fe(CN)(6)](3-/4-) indicator in solution and on electrochemical impedance spectroscopy when the measurements can be performed in the same solution. For the last two types of measurements, the biosensor was also used with an interface between the SPCE and DNA formed by a composite of carboxylate

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrochimica Acta

ISSN

0013-4686

e-ISSN

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Volume of the periodical

71

Issue of the periodical within the volume

Jene

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

134-139

UT code for WoS article

000304510900021

EID of the result in the Scopus database

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