Interactions of Platinum-Based Cytostatics with Metallothionein Revealed by Electrochemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10135339" target="_blank" >RIV/00216208:11310/13:10135339 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/13:00213015 RIV/00216208:11130/13:10135339 RIV/62157124:16270/13:43872362 RIV/00216305:26620/13:PU103768 RIV/00064203:_____/13:10135339
Result on the web
<a href="http://www.electrochemsci.org/papers/vol8/80404472.pdf" target="_blank" >http://www.electrochemsci.org/papers/vol8/80404472.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Interactions of Platinum-Based Cytostatics with Metallothionein Revealed by Electrochemistry
Original language description
Platinum-based cytostatics play an important role in the chemotherapy of various tumour diseases. Therefore, it is not surprising that there is a great effort for studying of the cytostatics and their fate in an organism. In this study, we aimed our attention at determination of cisplatin, carboplatin and oxaliplatin using stationary and flow electrochemical methods. Primarily, determination of the platinum based cytostatics using differential pulse voltammetry at hanging mercury drop electrode was optimized. Under the optimal conditions (supporting electrolyte: 2 ml of 0.36 M sulphuric acid containing 0.24 ml of hydrazine (10 mM) and 0.01 ml of formaldehyde (37 % aqueous solution, v/v), pH of the supporting electrolyte: 1.8, potential of accumulation:-0.7 V, time of accumulation: 120 s), limits of detection were estimated (3 S/N) down to tens of pg per ml for the studied drugs. Further, we investigated the interactions of the characterized drugs with peptide fragments of protein meta
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
RS - THE REPUBLIC OF SERBIA
Number of pages
13
Pages from-to
4472-4484
UT code for WoS article
000318217200009
EID of the result in the Scopus database
—