Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10159019" target="_blank" >RIV/00216208:11310/13:10159019 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/13:00396273 RIV/00216224:14310/13:00073056

Result on the web

<a href="http://dx.doi.org/10.1186/1471-2148-13-194" target="_blank" >http://dx.doi.org/10.1186/1471-2148-13-194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2148-13-194" target="_blank" >10.1186/1471-2148-13-194</a>

Result language

angličtina

Original language name

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Original language description

In this study we analysed the natural variation and the evolutionary processes acting on two genes involved in the innate-immunity recognition of Microbe-Associated Molecular Patterns (MAMPs). We sequenced genes encoding Toll-like receptor 4 (Tlr4) and 7(Tlr7), two of the key bacterial- and viralsensing receptors of innate immunity, across 23 species within the subfamily Murinae. Although we have shown that the phylogeny of both Tlr genes is largely congruent with the phylogeny of rodents based on a comparably sized non-immune sequence dataset, we also identified several potentially important discrepancies. The sequence analyses revealed that major parts of both Tlrs are evolving under strong purifying selection, likely due to functional constraints.Yet, also several signatures of positive selection have been found in both genes, with more intense signal in the bacterial-sensing Tlr4 than in the viral-sensing Tlr7. 92% and 100% of sites evolving under positive selection in Tlr4 and T

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

<a href="/en/project/GA206%2F08%2F0640" target="_blank" >GA206/08/0640: Immunogenetic study of a house mouse hybrid zone</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Evolutionary Biology

ISSN

1471-2148

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

194

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

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UT code for WoS article

000324749400001

EID of the result in the Scopus database

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