Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10272121" target="_blank" >RIV/00216208:11310/14:10272121 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00430232
Result on the web
<a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >http://dx.doi.org/10.1111/imm.12219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >10.1111/imm.12219</a>

Result language
angličtina
Original language name
Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells
Original language description
Regulatory T cells have been well described and the factors regulating their development and function have been identified. Recently, a growing body of evidence has documented the existence of interleukin-10 (IL-10) -producing B cells, which are called regulatory B10 cells. These cells attenuate autoimmune, inflammatory and transplantation reactions, and the main mechanism of their inhibitory action is the production of IL-10. We show that the production of IL-10 by lipopolysaccharide-stimulated B cellsis significantly enhanced by IL-12 and interferon- and negatively regulated by IL-21 and transforming growth factor-. In addition, exogenous IL-10 also inhibits B-cell proliferation and the expression of the IL-10 gene in lipopolysaccharide-stimulated Bcells. The negative autoregulation of IL-10 production is supported by the observation that the inclusion of anti-IL-10 receptor monoclonal antibody enhances IL-10 production and the proliferation of activated B cells. The effects of cyt
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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