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Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10272121" target="_blank" >RIV/00216208:11310/14:10272121 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/14:00430232

  • Result on the web

    <a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >http://dx.doi.org/10.1111/imm.12219</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >10.1111/imm.12219</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

  • Original language description

    Regulatory T cells have been well described and the factors regulating their development and function have been identified. Recently, a growing body of evidence has documented the existence of interleukin-10 (IL-10) -producing B cells, which are called regulatory B10 cells. These cells attenuate autoimmune, inflammatory and transplantation reactions, and the main mechanism of their inhibitory action is the production of IL-10. We show that the production of IL-10 by lipopolysaccharide-stimulated B cellsis significantly enhanced by IL-12 and interferon- and negatively regulated by IL-21 and transforming growth factor-. In addition, exogenous IL-10 also inhibits B-cell proliferation and the expression of the IL-10 gene in lipopolysaccharide-stimulated Bcells. The negative autoregulation of IL-10 production is supported by the observation that the inclusion of anti-IL-10 receptor monoclonal antibody enhances IL-10 production and the proliferation of activated B cells. The effects of cyt

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Immunology

  • ISSN

    0019-2805

  • e-ISSN

  • Volume of the periodical

    141

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    13

  • Pages from-to

    577-586

  • UT code for WoS article

    000332474100010

  • EID of the result in the Scopus database