Histone deacetylase inhibitors in cancer therapy. A review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282757" target="_blank" >RIV/00216208:11310/14:10282757 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/14:00225119 RIV/00216208:11130/14:10282757 RIV/00216305:26620/14:PU112642 RIV/00064203:_____/14:10282757
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2013.085" target="_blank" >http://dx.doi.org/10.5507/bp.2013.085</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2013.085" target="_blank" >10.5507/bp.2013.085</a>
Alternative languages
Result language
angličtina
Original language name
Histone deacetylase inhibitors in cancer therapy. A review
Original language description
Background. Despite recent success toward discovery of more effective anticancer drugs, chemoresistance remains a major cause of treatment failure. There is emerging evidence that epigenetics plays a key role in the development of the resistance. Epigenetic regulators such as histone acetyltransferases (HATs) and histone deacetylases (HDACs) play an important role in gene expression. The latter are found to be commonly linked with many types of cancers and influence cancer development. Overall, histoneacetylation is being investigated as a therapeutic target because of its importance in regulating gene expression. This review summarizes mechanisms of the anticancer effects of histone deacetylase (HDAC) inhibitors and the results of clinical studies. Results. Different HDAC inhibitors induce cancer cell death by different mechanisms that include changes in gene expression and alteration of both histone and non-histone proteins. Enhanced histone acetylation in tumors results in modifica
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
158
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
161-169
UT code for WoS article
000338628200001
EID of the result in the Scopus database
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