Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41320%2F18%3A78800" target="_blank" >RIV/60460709:41320/18:78800 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12864-018-5323-4" target="_blank" >http://dx.doi.org/10.1186/s12864-018-5323-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12864-018-5323-4" target="_blank" >10.1186/s12864-018-5323-4</a>
Alternative languages
Result language
angličtina
Original language name
Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action
Original language description
BackgroundEpigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.ResultsExposure of Tribolium castaneum cells (TcA cells) to JH or TSA caused an increase in expression of Kr-h1 (a known JH-response gene) and 31 or 698 other genes respectively. Knockdown of the gene coding for CBP caused a decrease in the expression of 456 genes including Kr-h1. Int
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20801 - Environmental biotechnology
Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC GENOMICS
ISSN
1471-2164
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
DEC2018
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
15
Pages from-to
1-15
UT code for WoS article
000453235700004
EID of the result in the Scopus database
2-s2.0-85058599981