Multiple functions of CREB-binding protein during postembryonic development: identification of target genes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41320%2F17%3A76003" target="_blank" >RIV/60460709:41320/17:76003 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12864-017-4373-3" target="_blank" >http://dx.doi.org/10.1186/s12864-017-4373-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12864-017-4373-3" target="_blank" >10.1186/s12864-017-4373-3</a>
Alternative languages
Result language
angličtina
Original language name
Multiple functions of CREB-binding protein during postembryonic development: identification of target genes
Original language description
Background: Juvenile hormones (JH) and ecdysteroids control postembryonic development in insects. They serve as valuable targets for pest management. Hence, understanding the molecular mechanisms of their action is of crucial importance. CREB-binding protein (CBP) is a universal transcriptional co-regulator. It controls the expression of several genes including those from hormone signaling pathways through co-activation of many transcription factors. However, the role of CBP during postembryonic development in insects is not well understood. Therefore, we have studied the role of CBP in postembryonic development in Tribolium, a model coleopteran insect. Results: CBP is ubiquitously expressed in the red flour beetle, Tribolium castaneum. RNA interference (RNAi) mediated knockdown of CBP resulted in a decrease in JH induction of Kr-h1 gene expression in Tribolium larvae and led to a block in their development. Moreover, the injection of CBP double-stranded RNA (dsRNA) showed lethal phenotypes within
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC GENOMICS
ISSN
1471-2164
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
996
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
14
Pages from-to
1-14
UT code for WoS article
000419229900002
EID of the result in the Scopus database
2-s2.0-85039733795