Coiled Coil Peptides and Polymer-Peptide Conjugates: Synthesis, Self-Assembly, Characterization and Potential in Drug Delivery Systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288605" target="_blank" >RIV/00216208:11310/14:10288605 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/14:00429827 RIV/61388963:_____/14:00429827
Result on the web
<a href="http://dx.doi.org/10.1021/bm500436p" target="_blank" >http://dx.doi.org/10.1021/bm500436p</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/bm500436p" target="_blank" >10.1021/bm500436p</a>
Alternative languages
Result language
angličtina
Original language name
Coiled Coil Peptides and Polymer-Peptide Conjugates: Synthesis, Self-Assembly, Characterization and Potential in Drug Delivery Systems
Original language description
Coiled coils are a common structural motif in many natural proteins that can also be utilized in the design and preparation of drug delivery systems for the noncovalent connection of two macromolecules. In this work, two different pairs of peptides forming coiled coil hetero-oligomers were designed, synthesized, and characterized. While the peptide sequences (VAALEKE)(4) and (VAALKEK)(4) predominantly form coiled coil heterodimers with randomly orientated peptide chains, (IAALESE)(2)-IAALESKIAALESE andIAALK-SKIAALKSE-(IAALKSK)(2) tend to form higher hetero-oligomers with an antiparallel orientation of their peptide chains. The associative behavior of these peptides was studied in aqueous solutions using circular dichroism spectroscopy, size-exclusionchromatography, isothermal titration calorimetry and sedimentation analyses. The orientation of the peptide chains in the coiled coil heterodimers was assessed using fluorescence spectroscopy with fluorescence resonance energy transfer la
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GCP207%2F12%2FJ030" target="_blank" >GCP207/12/J030: STIMULI RESPONSIVE NANOCARRIERS FOR HIGHLY EFFICIENT POLYMER THERAPEUTICS</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2590-2599
UT code for WoS article
000339090500027
EID of the result in the Scopus database
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