Synthesis and biological activity of nitrogen-containing derivatives of estafiatin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10332061" target="_blank" >RIV/00216208:11310/14:10332061 - isvavai.cz</a>
Result on the web
<a href="http://vestnik.ksu.kz/files_vestnik/Chemistry/Chemistry_2_74_2014.pdf" target="_blank" >http://vestnik.ksu.kz/files_vestnik/Chemistry/Chemistry_2_74_2014.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and biological activity of nitrogen-containing derivatives of estafiatin
Original language description
The reactions of guaianolide of estafiatin with various amines were investigated. It was shown that the aminolysis reactions of γ-lactone ring of estafiatin or reactions of Michael-type conjugate addition or tandem conversions of Michael and Knoevenagel-type were carried out depending on the nature of amines. The regularity of proceeding of estafiatin reactions with secondary aliphatic and aliphatic-aromatic amines was detected. It lies in the fact that the reactions proceed exclusively by Michael reaction and they are completely regioand stereoselective. It was revealed that synthetic nitrogen-containing derivatives of estafiatin had antibacterial and antioxidant activity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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