Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10295343" target="_blank" >RIV/00216208:11310/15:10295343 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2015/838035" target="_blank" >http://dx.doi.org/10.1155/2015/838035</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/838035" target="_blank" >10.1155/2015/838035</a>
Alternative languages
Result language
angličtina
Original language name
Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?
Original language description
Immunity exhibits extraordinarily high levels of variation. Evolution of the immune system in response to host-pathogen interactions in particular ecological contexts appears to be frequently associated with diversifying selection increasing the geneticvariability. Many studies have documented that immunologically relevant polymorphism observed today may be tens of millions years old and may predate the emergence of present species. This pattern can be explained by the concept of trans-species polymorphism (TSP) predicting the maintenance and sharing of favourable functionally important alleles of immune-related genes between species due to ongoing balancing selection. Despite the generality of this concept explaining the long-lasting adaptive variation inherited from ancestors, current research in TSP has vastly focused only on major histocompatibility complex (MHC). In this review we summarise the evidence available on TSP in human and animal immune genes to reveal that TSP is not a
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EG - Zoology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-11782S" target="_blank" >GA15-11782S: Biology of ageing: mechanisms and patterns of senescence in free-living birds</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Immunology Research
ISSN
2314-8861
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
neuvedeno
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
000355951500001
EID of the result in the Scopus database
2-s2.0-84935859204