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Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314365" target="_blank" >RIV/00216208:11310/15:10314365 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/15:00453444 RIV/61388963:_____/15:00453444 RIV/00216224:14740/15:00081380

  • Result on the web

    <a href="http://dx.doi.org/10.1002/chem.201502209" target="_blank" >http://dx.doi.org/10.1002/chem.201502209</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/chem.201502209" target="_blank" >10.1002/chem.201502209</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking

  • Original language description

    N-(3-Azidopropyl)vinylsulfonamide was developed as a new bifunctional bioconjugation reagent suitable for the cross-linking of biomolecules through copper(I)-catalyzed azide-alkyne cycloaddition and thiol Michael addition reactions under biorthogonal conditions. The reagent is easily clicked to an acetylene-containing DNA or protein and then reacts with cysteine-containing peptides or proteins to form covalent cross-links. Several examples of bioconjugations of ethynyl- or octadiynyl-modified DNA with peptides, p53 protein, or alkyne-modified human carbonic anhydrase with peptides are given.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chemistry - A European Journal

  • ISSN

    0947-6539

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    45

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    12

  • Pages from-to

    16091-16102

  • UT code for WoS article

    000363890700030

  • EID of the result in the Scopus database

    2-s2.0-84945476915