Spectrometric determination of trimethoprim and sulfamethoxazole in tablets by automated sequential injection technique
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10423509" target="_blank" >RIV/00216208:11310/20:10423509 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ESfs0p3Ryl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ESfs0p3Ryl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-020-02631-4" target="_blank" >10.1007/s00706-020-02631-4</a>
Alternative languages
Result language
angličtina
Original language name
Spectrometric determination of trimethoprim and sulfamethoxazole in tablets by automated sequential injection technique
Original language description
An automated sequential injection analysis with spectrometric detection for the determination of trimethoprim and sulfamethoxazole in tablets is proposed. The concentration of sulfamethoxazole is determined by monitoring the absorbance at 540 nm due to the intensively colored complex formed by derivatization reaction of sulfamethoxazole with nitrite and N-(1-naphthyl)ethylenediamine in acidic media. With knowledge of the sulfamethoxazole concentration, the trimethoprim concentration can be calculated from the absorption of the sample solution at 264 nm, where both analytes absorb, and the additivity of individual absorbances according to Beer-Lambert law can be used. The developed method has a linear dynamic range of 0.03-5.0 mg dm(-3) and a detection limit of 0.03 mg dm(-3) for trimethoprim and a linear dynamic range of 0.1-10.0 mg dm(-3) and a detection limit of 0.01 mg dm(-3) for sulfamethoxazole. The sampling frequency of the method is 24 h(-1). The method was successfully applied on pharmaceutical dosage form of tablets, as the results of the determination are in a good agreement with the official pharmacopoeial method (HPLC). The developed sequential injection analysis is simpler, cheaper, and faster than already published methods and pharmacopoeial assay. So it appears to be suitable for quality control in the pharmaceutical industry.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie - Chemical Monthly
ISSN
0026-9247
e-ISSN
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Volume of the periodical
151
Issue of the periodical within the volume
8
Country of publishing house
AT - AUSTRIA
Number of pages
6
Pages from-to
1311-1316
UT code for WoS article
000537679200003
EID of the result in the Scopus database
2-s2.0-85085975314