Determination of chlorpromazine, levomepromazine, and promethazine by sequential injection analysis with VIS spectrometric or spectrofluorimetric detection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10454775" target="_blank" >RIV/00216208:11310/22:10454775 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tdkG.l9zM8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tdkG.l9zM8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-022-02935-7" target="_blank" >10.1007/s00706-022-02935-7</a>

Result language

angličtina

Original language name

Determination of chlorpromazine, levomepromazine, and promethazine by sequential injection analysis with VIS spectrometric or spectrofluorimetric detection

Original language description

Automatic sequential injection analysis (SIA) with spectrometric or spectrofluorimetric detection is presented for the determination of three selected phenothiazines (chlorpromazine, levomepromazine, and promethazine) in pharmaceutical formulations. The determination is based on the oxidation of phenothiazine by cerium(IV) in acidic media, which leads to the formation of a color product that is detected by either VIS spectrometry or spectrofluorimetry. The conditions of SIA were optimized and second-order polynomial calibration equations were established in a dynamic range of 3-350 mg dm(-3) for VIS detection, 0.05-50 mg dm(-3) for spectrofluorimetric detection, respectively. The limit of quantitation was established 0.31 mg dm(-3) for VIS detection, 2.6 x 10(-3) mg dm(-3) for spectrofluorimetric detection, respectively. The sample throughput was 24 h(-1) for VIS spectrometric, 20 h(-1) for spectrofluorimetric, respectively, detection. Common excipients of the dosage forms (fructose, glucose, lactose) did not affect the measurement even at concentrations 200 times higher than phenothiazine. The method was used for the phenothiazine assay in authentic samples of commercial pharmaceutical formulations, and the results were in good agreement with the official pharmacopoeial method. The advantages of the developed SIA method are its complete automation, speed, very low reagent consumption, and a wide dynamic range of analyte concentrations, enabling it to be advantageously used for routine product control in the pharmaceutical industry.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

1434-4475

Volume of the periodical

153

Issue of the periodical within the volume

9

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

781-787

UT code for WoS article

000810239200001

EID of the result in the Scopus database

2-s2.0-85131679791