Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10436992" target="_blank" >RIV/00216208:11310/21:10436992 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.HzmaPTlKf" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.HzmaPTlKf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rstb.2020.0102" target="_blank" >10.1098/rstb.2020.0102</a>

Result language

angličtina

Original language name

Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos

Original language description

Differentiation of sex chromosomes is thought to have evolved with cessation of recombination and subsequent loss of genes from the degenerated partner (Y and W) of sex chromosomes, which in turn leads to imbalance of gene dosage between sexes. Based on work with traditional model species, theory suggests that unequal gene copy numbers lead to the evolution of mechanisms to counter this imbalance. Dosage compensation, or at least achieving dosage balance in expression of sex-linked genes between sexes, has largely been documented in lineages with male heterogamety (XX/XY sex determination), while ZZ/ZW systems are assumed to be usually associated with the lack of chromosome-wide gene dose regulatory mechanisms. Here, we document that although the pygopodid geckos evolved male heterogamety with a degenerated Y chromosome 32-72 Ma, one species in particular, Burton&apos;s legless lizard (Lialis burtonis), does not possess dosage balance in the expression of genes in its X-specific region. We summarize studies on gene dose regulatory mechanisms in animals and conclude that there is in them no significant dichotomy between male and female heterogamety. We speculate that gene dose regulatory mechanisms are likely to be related to the general mechanisms of sex determination instead of type of heterogamety. This article is part of the theme issue &apos;Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part II)&apos;.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

<a href="/en/project/GA19-19672S" target="_blank" >GA19-19672S: When the half could be equal to the whole: Evolution of dosage compensation in squamate reptiles</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Philosophical Transactions of the Royal Society B: Biological Sciences

ISSN

0962-8436

e-ISSN

—

Volume of the periodical

376

Issue of the periodical within the volume

1833

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

20200102

UT code for WoS article

000677659100005

EID of the result in the Scopus database

2-s2.0-85097364392