Genomic imprinting mediates dosage compensation in a young plant XY system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F18%3A00495629" target="_blank" >RIV/61389030:_____/18:00495629 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00495090
Result on the web
<a href="http://dx.doi.org/10.1038/s41477-018-0221-y" target="_blank" >http://dx.doi.org/10.1038/s41477-018-0221-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41477-018-0221-y" target="_blank" >10.1038/s41477-018-0221-y</a>

Result language
angličtina
Original language name
Genomic imprinting mediates dosage compensation in a young plant XY system
Original language description
Sex chromosomes have repeatedly evolved from a pair of autosomes. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced expression and eventual loss of Y genes(1). The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these negative effects has been described in animals(2-4). However, the early steps in the evolution of dosage compensation remain unknown, and dosage compensation is poorly understood in plants(5). Here, we describe a dosage compensation mechanism in the evolutionarily young XY sex determination system of the plant Silene latifolia. Genomic imprinting results in higher expression from the maternal X chromosome in both males and females. This compensates for reduced Y expression in males, but results in X overexpression in females and may be detrimental. It could represent a transient early stage in the evolution of dosage compensation. Our finding has striking resemblance to the first stage proposed by Ohno(6) for the evolution of X inactivation in mammals.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany

Project
<a href="/en/project/GA16-08698S" target="_blank" >GA16-08698S: Origin and evolution of sex chromosomes in the dioecious plant Rumex acetosa</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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