Ga(III) pyridinecarboxylate complexes: Potential analogues of the second generation of therapeutic Ga(III) complexes?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10467194" target="_blank" >RIV/00216208:11310/23:10467194 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p.o238Ifhc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p.o238Ifhc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-023-02012-2" target="_blank" >10.1007/s00775-023-02012-2</a>
Alternative languages
Result language
angličtina
Original language name
Ga(III) pyridinecarboxylate complexes: Potential analogues of the second generation of therapeutic Ga(III) complexes?
Original language description
A series of novel Ga(III)-pyridine carboxylates ([Ga(Pic)(3)].H2O (GaPic; HPic = picolinic acid), H3O[Ga(Dpic)(2)].H2O (GaDpic; H(2)Dpic = dipicolinic acid), [Ga(Chel)(H2O)(OH)](2).4H2O (GaChel; H(2)Chel = chelidamic acid) and [Ga(Cldpic)(H2O)(OH)](2) (GaCldpic; H(2)Cldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis and X-ray diffraction confirmed complexes molecular structure, inter and intramolecular interactions and their influence to spectral and thermal properties. Moreover, complex species speciation was described in Ga(III)-HPic and Ga(III)-H(2)Dpic systems by potentiometry and (1)H NMR spectroscopy and mononuclear complex species were determined; [Ga(Pic)(2)](+) (log β(021) = 16.23(6)), [Ga(Pic)(3)] (log β(031) = 20.86(2)), [Ga(Dpic)(2)](-) (log β(021) = 15.42(9)) and [Ga(Dpic)(2)(OH)](2-) (log β(-121) = 11.08(4)). To confirm the complexes stability in 1% DMSO (primary solvent for biological testing), timescale (1)H NMR spectra were measured (immediately after dissolution up to 96 h). Antimicrobial activity evaluated by IC50 (0.05 mM) is significant for GaDpic and GaCldpic against difficult to treat and multi-resistant P. aeruginosa. On the other hand, the GaPic complex is most effective against Jurkat, MDA-MB-231 and A2058 cancer cell lines and significantly also decreases the HepG2 cancer cells viability at 75 and 100 μM concentrations in a relatively short time (up to 48 h). In addition, fluorescence measurements have been used to elucidate bovine serum albumin binding activity between ligands, Ga(III) complexes and bovine serum albumin.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Inorganic Chemistry
ISSN
0949-8257
e-ISSN
1432-1327
Volume of the periodical
28
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
21
Pages from-to
591-611
UT code for WoS article
001038544600001
EID of the result in the Scopus database
2-s2.0-85165928099