Silver(I), Zinc(II) and Gallium(III) thiophene-2-carboxylates: Synthesis, solution and solid state characterization and bioevaluation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F25%3A00636663" target="_blank" >RIV/61388955:_____/25:00636663 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/25:10498268

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0162013425001163?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0162013425001163?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2025.112936" target="_blank" >10.1016/j.jinorgbio.2025.112936</a>

Result language

angličtina

Original language name

Silver(I), Zinc(II) and Gallium(III) thiophene-2-carboxylates: Synthesis, solution and solid state characterization and bioevaluation

Original language description

Three 2-thiophenecarboxylate (Tio2c) complexes with different central atoms Ag(I), Zn(II) and Ga(III), [Ag(Tio2c)]2 (AgTio2c), {[Zn2(Tio2c)4]2}n (ZnTio2c) and [Ga(Tio2c)3]·H2O (GaTio2c), were synthesized and elemental, spectral and thermal analyses were used for their characterization. The AgTio2c and ZnTio2c single crystal structures confirmed the most common bidentate bridging coordination mode with typical strong argentophilic interactions in the case of AgTio2c complex. Complexes' stability in biological test stock solution were confirmed by 1H NMR spectroscopy. Potentiometric data analysis by BSTAC program resulted in the determination of the stability constants of four complex species, [Zn(Tio2c)]+ (log β110 = 2.06 ± 0.04), [Zn(Tio2c)(OH)] (log β11–1 = −5.0 ± 0.1), [Zn(Tio2c)(OH)2]− (log β11–2 = −12.9 ± 0.4) and [Zn(Tio2c)2(OH)2]2− (log β12–2 = −8.54 ± 0.04) with low abundance in aqueous solution. Theoretical estimation of the complex species in aqueous solution indicates a rather monodentate Tio2c coordination mode in the [Zn(Tio2c)]+ species, while the hydroxido complex species prefer a rather bidentate O,Oʼ-bond of the carboxylate. Antimicrobial and anticancer bioassays clearly confirmed the highest biological activity (toxicity) of the AgTio2c complex. The activity of ZnTio2c was slightly higher (or the same) compared to GaTio2c. The HSA (human serum albumin) binding behaviour of the AgTio2c, ZnTio2c and GaTio2c complexes was investigated using fluorescence spectroscopy and results revealed that the calculated Kb values were in the order of 104 M−1.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

1873-3344

Volume of the periodical

270

Issue of the periodical within the volume

SEP 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

112936

UT code for WoS article

001487098600001

EID of the result in the Scopus database

2-s2.0-105004034423