STING regulation in polyomavirus infections
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10482084" target="_blank" >RIV/00216208:11310/24:10482084 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
STING regulation in polyomavirus infections
Original language description
Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses resulted in cGAS-STING pathway activation but only moderate interferon beta production was detected indicating possible regulation of the pathway during the infection. STING is a transmembrane protein that predominantly resides in the endoplasmic reticulum (ER). After binding to cGAMP di-nucleotide, STING oligomerizes. Oligomers translocate from ER to trans Golgi reticulum which leads to TBK1 and IRF3 phosphorylation and subsequent interferon-beta production. Later, STING is degraded in proteasomes or autophagosomes.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů