STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10469285" target="_blank" >RIV/00216208:11310/23:10469285 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
STING agonists induce robust cytokine secretion and rapid monocyte cell death in peripheral blood mononuclear cells
Original language description
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway plays a central role in recognition of the double-stranded DNA in cytoplasm, a sign of cell damage or infection. Upon activation, the pathway triggers production of interferons and proinflammatory cytokines by immune cells. These immune mediators further modulate regulatory immune processes with antitumoral and antiviral properties. Therefore, activators of the cGAS-STING pathway are being investigated for their therapeutic potential.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů