D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F08%3A00100819" target="_blank" >RIV/00216208:11320/08:00100819 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/08:00313426 RIV/60461373:22330/08:00019966
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein
Original language description
Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of Mason-Pfizer monkey virus (M-PMV) polyproteins to the cytoplasmic assembly site. Comparison ofthe three-dimensional structures of M-PMV wild-type matrix protein (wt MA) with a single amino acid mutant (R55F), which redirects assembly from a cytoplasmic site to the plasma membrane, revealed different mutual orientations of their C- and N-terminaldomains. This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule.
Czech name
řízení morfogenetického přepínače D-retroviru pomocí přístupnosti signálni sekvence Tctexu z Dyneinu
Czech description
řízení morfogenetického přepínače D-retroviru pomocí přístupnosti signálni sekvence Tctexu z Dyneinu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
30
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000258211600053
EID of the result in the Scopus database
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