Mason-Pfizer monkey virus matrix protein - the structural study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012834" target="_blank" >RIV/60461373:22330/04:00012834 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Mason-Pfizer monkey virus matrix protein - the structural study
Original language description
The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus.It was shown that single point mutation in position 55 of the matrix protein of M-PMV chan
Czech name
Strukturní studie matrixového proteinu Mason-Pfizerova opičího viru
Czech description
Strukturní studie matrixového proteinu Mason-Pfizerova opičího viru
Classification
Type
D - Article in proceedings
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the XIX. meeting of czech and slovak societies for biochemistry and molecula r biology
ISBN
0232-0061/80-24
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
96
Publisher name
Univerzita Palackého
Place of publication
Olomouc
Event location
Olomouc
Event date
Jan 1, 2004
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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