Assembly of M-PMV retroviral capsids in vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012742" target="_blank" >RIV/60461373:22330/04:00012742 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Assembly of M-PMV retroviral capsids in vitro
Original language description
Retroviruses are subject of intensive studies not only in context with AIDS pandemia and oncogenic effect on several organisms including human. The understanding of retroviral capsid assembly mechanisms and nucleic acids incorporation could significantlycontribute to further use of these systems for therapeutic purposes. Our research is focused on study of forming of Mason-Pfizer monkey virus (M-PMV) immature capsids in vitro. M PMV as the prototype of D-type retrovirus is an excellent model for assembly studies. These retroviruses are characterized by the assembly of intracytoplasmic capsids, which make their way to the plasma membrane and are released by budding. Gag polyproteins of all retroviruses contain domains corresponding to the structural proteins which are important for driving the assembly process, namely matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.We have found specific conditions under which we can prepare properly assembled capsids in vitro from structural p
Czech name
Skládání MPMV kapsid in vitro
Czech description
Skládání MPMV kapsid in vitro

Project
<a href="/en/project/LN00A079" target="_blank" >LN00A079: Center of Integrated Genomics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the XIX. meeting of czech and slovak societies for biochemistry and molecular biology
ISBN
0232-0061
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
96-97
Publisher name
Univerzita Palackého
Place of publication
Olomouc
Event location
Olomouc
Event date
Jan 1, 2004
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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